Breast cancer is the most common malignancy in women and the second
leading cause of cancer death (exceeded by lung cancer in 1985). Breast
cancer is three times more common than all gynecologic malignancies put
together. The incidence of breast cancer has been increasing steadily
from an incidence of 1:20 in 1960 to 1:8 women today.The American
Cancer Society estimates that 211,000 new cases of invasive breast
cancer will be diagnosed this year and 43,300 patients will die from the
disease. Breast cancer is truly an epidemic among women and we don't
know why.
Breast cancer is not exclusively a disease of women. For every 100
women with breast cancer, 1 male will develop the disease. The American
Cancer society estimates that 1,600 men will develop the disease this
year. The evaluation of men with breast masses is similar to that in
women, including mammography.
The incidence of breast cancer is very low in the twenties (age)
gradually increases and plateaus at the age of forty-five and increases
dramatically after fifty. Fifty percent of breast cancer is diagnosed in
women over sixty-five indicating the ongoing necessity of yearly
screening throughout a woman's life.
Breast cancer is considered a heterogenous disease, meaning that it
is a different disease in different women, a different disease in
different age groups and has different cell populations within the tumor
itself. Generally, breast cancer is a much more aggressive disease in
younger women. Autopsy studies show that 2% of the population has
undiagnosed breast cancer at the time of death. Older women typically
have much less aggressive disease than younger women.