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Home / Information / Page 3 /Could fingerprints hold the clue to breast cancer mystery?

Could fingerprints hold the clue to breast cancer mystery?

A high school science project inspires researchers to focus on fingerprints as
possible genetic marker for increased risk of breast cancer

Toronto – Identifying women at increased risk of breast cancer may one day be as easy as taking a fingerprint.

Dr. Linda Cook of the Alberta Cancer Board and the University of Calgary has received funding from the Canadian Breast Cancer Research Initiative to complete a one-year project Digital Dermatoglyphics and a Family History of Breast Cancer.

“It is well known that there is a genetic component to breast cancer. Two genes (BRCA1 and BRCA2) have been identified as genetic links, but these account for only a small proportion of cases,” says epidemiologist Dr. Cook. “We have some evidence from a small study to suggest that a family history of breast cancer might be associated with a specific fingerprint pattern. If we do find an association, fingerprints might potentially be used for screening or to guide future research.”

This novel idea has direct roots in a Calgary science fair project of Breanne Everett and Caitlin Hicks. The two grade twelve students knew that fingerprints have been studied as diagnostic indicators for genetic diseases such as schizophrenia. To see if a distinct fingerprint could also indicate increased risk of breast cancer, the students used a free software program from the FBI and analyzed the fingerprints of volunteers.

Their study, while rudimentary, did show promise (and captured first place at the science fair). A University of Calgary researcher judging the science fair put the students in touch with Dr. Cook. With the students as junior collaborators, Dr. Cook applied and was awarded a $40,000 grant from the Canadian Breast Cancer Research Initiative to conduct a formal study on the novel diagnostic indicator.

Fingerprints of women 20 to 69 years of age from the Calgary Health Region will be used to assess whether a right loop thumb print pattern is more likely to indicate a first degree family history of breast/ovarian cancer than an arch, whorl, tent, or left loop thumb print pattern. The local Calgary Police Department has offered to train the researchers in expert fingerprinting methods to obtain the best quality samples.

“If we get positive results from this study, further research would then be warranted to start to address the underlying biology and genetics of this relationship, “says Dr. Cook, “as well as the value of dermatogylphic traits in predicting breast cancer risk.”

“The CBCRI is pleased to support Dr. Cook and her young collaborators as part of our IDEA Grants Program,” says Dr. Marilyn Schneider, executive director of the Canadian Breast Cancer Research Initiative. “CBCRI supports novel ideas such as this with small grants. If this project pays off, it could ultimately lead to big dividends for women.”

About CBCRI IDEA Grants
On April 1, 1999 the Canadian Breast Cancer Research Initiative (CBCRI) launched a new program to stimulate innovation, the IDEA Grants program. IDEA Grants fund highly innovative, speculative research projects that challenge existing paradigms. The grants are based on solid science and have the potential for advancing scientific knowledge. The expectation is that these ideas, once explored, may lead to the development of proposals for feasibility grants or operating grants. To date, CBCRI has funded 25 IDEA grants for Canadian researchers.

About CBCRI
Established in 1993, the Canadian Breast Cancer Research Initiative is Canada's primary funder of breast cancer research. To date, CBCRI has contributed $80.5 million to support 277 research grants. As a unique partnership of groups from the public, private and non-profit sectors, CBCRI is committed to reducing the incidence of breast cancer, increasing survival, and enhancing the lives of those affected by the disease. CBCRI partners include the Avon Flame Foundation, the Canadian Breast Cancer Foundation, the Canadian Breast Cancer Network, the Canadian Cancer Society, the Canadian Institutes of Health Research, Health Canada and the National Cancer Institute of Canada.
Source: http://www.fp.ucalgary.ca/unicomm/news/April_02/fingerprints.htm

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